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The Curie Institute is a private health care facility and not-for-profit organization that combines a leading European cancer research center with a peerless hospital group to treat breast cancer, pediatric cancer, and solid tumors, all while embracing Marie Curie’s stated purposes of the health care model she imagined: “From basic research to innovative treatments.”

 

The Curie Institute’s values revolve around innovation and multidisciplinary approach. Its commitments to developing advanced technology platforms and disseminating knowledge nationally and internationally aim to improve clinical medical practices, as well as research’s impact, across the scientific community. Since its foundation, it has made patient care, a commitment to research, and innovation its core priorities, in order to provide incomparable benefits to general health care and research. To this end, it has always promoted and encouraged multidisciplinary, cross-field, and innovative research to improve diagnostic screenings and therapeutic treatments.

To provide the best possible health care to every patient in treatment, the Curie Institute relies on two hospitals—Hôpital de Paris, located in the city center, and Hôpital René-Huguenin, located in Saint-Cloud—as well as a Proton Therapy Center, located in the academic town of Orsay.

The Curie Institute retains more than 2,200 employees. It houses more than 240 hospital beds and, in 2013, treated nearly 15,000 people for cancer. It has provided 167,000 medical consultations and welcomed 5000 new patients, for a total of 18,400 surgeries. Regarding day care and conventional hospitalizations, it has provided 39.400 chemotherapy and 99.000 radiotherapy sessions. These numbers reflect the Curie Institute’s renowned experience and reputation accumulated since its foundation, as well as ensures high-quality care and specialized, expert consultations.

The Curie Institute placed among the nation’s best hospitals in breast cancer treatments.

In the latest rankings of French Hospitals by the ‘Le Point’ magazine, the most important independent classification of Private and Public Health care institutions in France,the Curie Institute was ranked in the top 50 hospitals in the country. It was also ranked highly in the following areas on a national base:

Treatments for the cancers:

  • Breast (1)
  • Gynecological (3)
  • ENT (7)

source: the leading French weekly newsmagazine Le Point’s “2017 FRENCH BEST PRIVATE HOSPITALS” (Le Point’s hospital ranking is an established and influential one and presents an annual report of France’s hospitals and health care providers.)

Health Services and global care treatments

  • Senology (breast cancer, from screening to reconstructive surgery)
  • Gynecology
  • Prostate cancer (Curie therapy)
  • Hematological cancers (lymphomas and myelomas)
  • Pediatric oncology (solid tumors treated in-house and collaboration with Hôpital Necker for all surgical aspects)
  • Ophthalmology (adults with uveal melanoma, children with retinoblastoma)
  • Proton therapy (eye, head and neck, and vertebrae treatment for adults and children)
  • Genetics (somatic genetics, pharmacogenomics, and constitutional genetics with genetic clinics)
  • Neurological cancers
  • Skin cancers
  • Sarcomas (adults and children)
  • Gastrointestinal cancers
  • Otolaryngological (ENT) cancers
Departments

Curie’s Surgical Department includes several operative units and cooperates with other departments including radiotherapy, pediatrics, and digestive surgery, to offer optimal multidisciplinary management of patients in treating several diseases and pathologies.

Surgery is often an inevitable part of cancer treatment. At Curie, physicians recommend conservative or reconstructive surgery whenever possible, so that the treatment leaves the smallest possible traces.

SENOLOGY UNIT

The Senology Unit focuses on the diagnosis and management of benign and malignant diseases of the breast. Surgery is usually the first step of treatment after the diagnosis of breast cancer, and depending on the size, nature, and location of the tumor, various surgical techniques can be performed. Conventional surgery and new techniques of oncoplastic surgery used by the Breast Screening and Surgery Unit at the Curie Institute aim to manage the disease as non-invasively as possible. A dedicated reconstructive surgery unit allows the patients to have access to all latest techniques.

45% of the breast activity is done in the Ambulatory Surgical Department;

Institut Curie has been rated 1st and Best Hospital in the last national benchmarking (Le Point Magazine).

GYNECOLOGYUNIT

The Gynecology Unit provides women research-based care and expertise at every stage of the disease. .. The expertise of its surgeons, along with cutting-edge technology and internationally renowned experience, aim to protect and preserve women’s health at all ages.

PLASTIC SURGERY AND RECONSTRUCTIONAL SURGERY UNIT

The Plastic Surgery and Reconstructional Surgery Unit offers nationally and internationally recognized breast cancer specialists who focus their compassionate care, expertise, and research exclusively on helping patients to decide which option is best for their unique needs. Plastic and reconstructive surgeons of the breast guide patients through all surgery and pre-surgery processes, as well as inform and advise them on new, state-of-the-art techniques for specific pathologies and procedures.

PEDIATRIC AND ADOLESCENT ONCOLOGY DEPARTMENT

The Pediatric and Adolescent Oncology Department focuses entirely on the research and treatment of childhood cancers. As a leading cancer center in France, the Curie Institute is at the forefront of developing new treatments and designing clinical trials. Despite having the disease, it is important for children and teenagers to continue living their lives as normally as possible, particularly in an environment that allows them to grow and develop throughout treatment. That is the very reason at the Pediatric and Adolescent Oncology Department has established a special policy encompassing a wide range of facilities and programs to treat children and adolescents affected by solid tumors.

onco-radiotherapy and proton therapy

Proton therapy was first practiced in 1954 at Lawrence Berkeley Laboratory in Berkeley, USA. In the following years, it was introduced in Uppsala (Sweden), Harvard (USA), and in 1984 at the Paul Scherrer Institute (Switzerland). Over 60 years of experience now accompanies proton therapy practice, which has become one of the most advanced methods to irradiate tumors.

By the end of 2010, 23 hospital-based proton therapy centers were in operation around the world: eight in the USA, six in Japan, two in China, one in South Korea, four in Germany, one in Italy, and one in France. Since then, 20 have been under construction around the world, including 11 in Europe and six in the USA.

www.ptcs.ch/language/en-US/tabid/85/Home/Proton-Therapy/Proton-Therapy-worldwide.aspx

Since opening in 1991 and its complete renovation in 2010, Curie’s Proton Therapy Center has treated more than 5,500 patients, making it one of the most important platforms in Europe, by using the most advanced technology available and delivering personalized, comprehensive patient care. The Proton Therapy Center has a privileged partnership with two other hospitals—namely, the Gustave Roussy Cancer Institute and the Assistance Publique – Hôpitaux de Paris—both of which participate in the recruitment and preparatory treatment processes.

The only proton therapy center in the Paris region, the Institut Curie CPO, is located on the campus of Paris-Sud University at Orsay. It was founded around the particle accelerator for nuclear physics established by Irène and Fréderic Joliot Curie. With the CPO, France is equipped with unique cutting-edge technologies for treating cancers with advantageous new ballistic techniques, through proton therapy. In 2010, the old accelerator was replaced with a new cyclotron and the centre was renovated and expanded.

It treats more than 500 patients annually, from the whole of France and from abroad; they are treated in three treatment rooms, one of which is equipped with an isocentric arm.

In addition to its medical activities, the CPO is part of a network of expert groups and has forged scientific partnerships with the CNRS and the CEA for radioprotection, robotics, dosimetry, beam modeling and radiobiology, and with other centres around the world for R&D projects and for clinical collaborations.

Cutting-edge technological equipment and specialized facilities include:

  • Radiotherapy:
    Eight LINAC machines; two tomotherapy machines (with precise radiation beams to treat hard-to-reach tumors); one Novalis® radiosurgical machine (for high-precision stereotactic therapy); and two cyclotrons (dedicated to clinical use and research)
  • High-precision imaging:
    Two scanners; two MRIs; three gamma cameras; and two PET scanners
  • Operating rooms:
    10 in Paris and five in Saint-Cloud
  • Clinical trials:
    Inclusion rate of 15 % out of 2.200 patients in over 200 interventional studies
The Oncological Radiotherapy Department

The Radiotherapy Department of Institut Curie is one of the most complete in Europe and one of the largest in France. The technical platform includes particle accelerators generating photons and electrons (at the Paris and Saint-Cloud sites) and a cyclotron producing protons (at the Orsay site). These machines can be used for conformational techniques, with intensity modulation and irradiation by arc therapy or helical tomotherapy. The department has a brachytherapy unit delivering low-dose, low pulsed-dose and high-dose rate treatments. The department is well integrated into both a multidisciplinary medical environment (surgery, medical oncology, pediatric oncology) and a fundamental and translational research environment.

THE SCIENCE BEYOND

Proton therapy is one of the most precise noninvasive and nonsurgical treatments in external radiation therapy. Given its unique depth-dose characteristic, it delivers low doses of radiation never beyond the target volume and is therefore preferred for treating irregular solid tumors located near critical and sensitive organs and for pediatric therapy (under general anesthesia) and clinical trials.

EXPERTISE AND MULTiDISCIPLINARITY

The renowned specialists and physicians of the Proton Therapy Center include some of the most knowledgeable and skilled radiation oncologists.

Radiation oncologist physicians are specialized in treating cancer of the brain, breast, prostate, bladder, and every other organ and system in the body.

As an integral part of the Curie Institute—a highly multidisciplinary, specialized center for research and treating cancer—allows the Proton Therapy Center to work closely with medical oncologists and surgical oncologists who excel in the treatment of the disease and together can develop an optimal treatment plan for each patient.

These thorough, expert, and well-coordinated treatment plans make the Curie Institute one of the most active, welcoming centers in Europe, as well as one that can have extraordinary impacts on the quality of health care provided.

Embracing Marie Curie’s vision of offering everything from “basic research to innovative treatments,” physicians, physician–scientists, and physicists are actively devoted in creating close collaboration between health care and research in order to develop next-generation radiation therapies. Research is an essential part of the Curie Institute, where basic research, physics research, and clinical research are devoted to unveiling the causes and mechanisms of cancer with the primary purpose of translating that work into clinical practice.

The Curie Institute conducts research in order to:

  • Understand the mechanisms of cancer development
  • Facilitate the transition from basic research to clinical application
  • Develop innovative therapeutic and diagnostic techniques

Biologists, chemists, physicists, and computer scientists compose our multidisciplinary teams that have made the Curie Institute a leader in cancer studies in Europe. Its teams are divided into 14 research units that work closely with the National Center for Scientific Research (CNRS), INSERM, and various universities, including Paris Sciences et Lettres, Paris-Descartes, Pierre et Marie Curie, and Paris Sud.

On September 1, 2013, CNRS Research Director, Director of the Nuclear Dynamics and Genome Plasticity Unit, and Assistant Director of Teaching Geneviève Almouzni took over management of the Curie Institute.

RESEARCH CENTERS
  • Bank of characterized tissues (samples taken from the operating room)
  • Bank of characterized xenotransplants
  • Bank of transgenic mice
  • Chemolibrary (30% of the main « National Library » is coming from our library)..
  • Nikon Imaging Center (+Atomic force Microscopy, Electronic Microscopy, Multiphoton)
  • Cyclotron
  • High Content Screening: Biophenics platform
  • Functional validation (laser microdissection, in situ hybridization, siRNA)
  • High-thoughput sequencing (SOLIDtm)


Crédit photos (copyright) : Institut Curie, Uriel Chantraine